Neutrinos have come a long way in the human endeavor from their days as a ``desperate remedy.''  Their study now forms the cornerstone of the high energy physics program in the United States.  The U.S. will play host to an international project called DUNE which will explore many of the most important open questions in neutrino physics.  We discovered neutrino mass by doing long-distance quantum phase interferometry with large detectors that were both sensitive scientific instruments and exquisitely beautiful devices.  DUNE will employ an enormous liquid argon time-projection chamber to make the most thorough measurements of neutrino oscillation phenomena ever undertaken.  The large far detector will enable the exploration of a plethora of physical phenomena including nucleon decay and dark matter.  After briefly discussing the history of neutrinos, I will describe the measurements we will make with DUNE and some physics opportunities we will have along the way.